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|Title: ||Serum Levels of the Pyridinoline Crosslinked Carboxyterminal Telopeptide of Type 1 Collagen (ICTP) and Osteocalcin in Rachitic Children in Nigeria.|
|Authors: ||Scariano, John K.|
Walter, Elizabeth A.
Glew, Robert H.
Hollis, Bruce W.
Isichei, Christien O.
metabolic bone disease
|Issue Date: ||1995|
|Publisher: ||Clinical Biochemistry|
|Series/Report no.: ||Vol. 28;No.5; Pp 541-545|
|Abstract: ||Objectives: We measured the levels of the pyridinoline crosslinked carboxyterminal telopeptide of type I collagen (ICTP) and osteocalcin (OC) in the serum of 12 rachitic and 27 healthy Nigerian children, and compared the performance of these relatively new markers of bone metabolism with estab- lished laboratory parameters of skeletal disease. Design and Methods: Active rickets was diagnosed on the basis of clinical and biochemical criteria. Serum calcium and phos- phorus concentration and alkaline phosphatase activity were determined using clinically accepted methods. Radioimmuno- assay was performed to quantify parathyroid hormone, 1-,25- dihydroxyvitamin D, OC, and ICTP. Results: The rachitic children had statistically significant serum elevations of ICTP and osteocalcin as compared with age- and sex-matched controls. Serum levels of ICTP correlated with al- kaline phosphate activity. Conclusions: As a marker of abnormal bone metabolism, ICTP performs at least as well as alkaline phosphate. ICTP and OC are valuable additions to the growing repertoire of bone markers.|
|Appears in Collections:||Paediatrics|
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