Comparative Effects of Some Alcoholic Beverages on Hepatic Parameters in Experimental Animals

Abstract

The relationship between exposure to a variety of alcoholic beverages and the concomitant effects on the liver was monitored applying Spectrophotometric technique," to achieve this, the activities, in international units, IU, of serum alkaline phosphatase (ALP), alanine aminotransferase (ALT) were assayed; similarly, the concentrations of albumin, total proteins (g/litre) and hilirubin (mMole/litre) were determined. Animals were exposed to the alcoholic beverages for seven (7) and fourteen ( 14) consecutive days respectively. Results obtained, except for ALT activity in both Protocols where palm wine was administered (p>0,05), indicated time-dependent increases in both serum enzyrnes' activities and serum concentrations of albumin, bilirubin and total proteins as values for the test groups were higher and statistically significant (p<0. ()5 ) compared to control groups values. Base on the results obtained from this work, these alcoholic drinks have deleterious effects on the liver albeit to different magnitude: Gin, Ogogoro and Goskolo ranked topmostfollowed by beer and then palm wine in that order SPSS Statistical Softwareli 0 Windows was used and the student's t-test was chosen to analyse the data; P value 0. 05 was considered significant.