The Effects of Alcoholic Solutions of Salts of Some Metals on Some Nephrotic and Hepatic Biochemical Parameters in Male Albino Wistar Rats In viva

Abstract

The presence of inorganic toxicants in beers is a major health challenge; hence, understanding their interactions with ethyl alcohol in vivo becomes imperative. This study was designed therefore to monitor the effects of simultaneous oral co-exposure of male white albino Wistar rats to alcoholic solutions (3.04% v/v ethyl alcohol) of CaCl, Pb (CH_,()O),, Fe (NO), and ZnSO, continuously for seven days by analysing for some serum biochemical parameters of the liver (alanine amino transferase, ALT; aspartate amino transferase, AST; alkaline phosphatase, ALP; albumin, ALB, total protein, TP) and the kidney (creatinine, Cr and urea, Ur). Fifteen rats were divided into five groups of 3 rats each and, spectrophotometric techniques were applied to assay for the parameters. Results obtained showed elevated activities/concentration of all the parameters in the tests groups (p<0.05) indicating damage to the organs. On the liver the effects due to CdCl2 was the worst followed by Pb (CH,OO), Fe (NO,), and ZnSO, in that order; in the case of the kidney, the trend was.‘ CdClZ Fe (NO,), Pb (CH,OO) and ZnSO, These results suggest that salts of these metals do aggravate the toxic effects of ethyl alcohol on the organs but to different magnitudes. SPSS 15.0 statistical software was used and One Way ANOVA was chosen to analyse the data; p value = 0. 05 was considered significant.