Potentials of Methanolic Extract of N. Latifolia Stem Bark Against T. Congolense Infection in Experimental Rats

Abstract

Methanolic extract of Nauclea latifolia stem bark was investigated for antitrypanosomal activity using albino rats infected with Trypanosoma congolense. Fifteen albino rats placed in 5 groups of 3 each were labeled A to E. Groups A and B served as positive and negative controls, respectively. Groups C, D and E were infected with the parasites and treated with 100, 200 and 300mg/kg body weight of methanolic extract of Nauclea latifolia stem bark respectively. Parasitemia was monitored as well as hematological and biochemical parameters were analyzed. The results showed suppression in levels of parasites in all the infected and treated groups. Equally, the negative effects of the disease were lowered as shown in the hematological and biochemical parameters. The antitrypamosomal potential of the extracts was therefore demonstrated.