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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/1226

Title: Analgesic and Anti Inflammatory Activities of the Ethanolic Extract of the Mushroom Ganoderma Applanatum
Authors: Ede, Samuel O.
Olaniru, Edward
Otimenyin, Sunday
Aguiyi, John C.
Ekwere, Ekwere O.
Issue Date: Oct-2012
Publisher: International Journal of Recent Research and Applied Studies
Series/Report no.: Vol. 13;Iss. 1; Pp 349-352
Abstract: Objective: The ethanolic extract of the mushroom, Ganoderma applanatum was investigated for the presence of secondary metabolites, anti-inflammatory and analgesic activities. Material and Methods: The extract was subjected to phytochemical screening for the identification of secondary metabolites. Using intraperitoneal doses of 150, 300, 600 and 1200 mg/kg body weight, in vivo anti-inflammatory screening was carried out in rats using the rat paw oedema test while analgesic activity of the extract was done in mice using the hot plate test. Results: The study shows that the extract has an LD50 of 3273 mg/kg and the presence of anthraquinones, flavonoids and steroids. Saponins and tannins were absent. Dose and time dependent suppression of egg-white induced oedema in the rat paw test was observed, with maximum percentage suppression occurring at 600mg/kg (59.2%). The extract also significantly prolonged the reaction time in mice to noxious thermal stimuli. Conclusion: Ganoderma applanatum has potential as a source of useful analgesic and anti-inflammatory principles.
URI: http://hdl.handle.net/123456789/1226
Appears in Collections:Anatomy

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