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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/1639

Title: Subchronic Oral Toxicity of the Aqueous Leaf Extract of AnogeissusLeiocarpus on Albino Rats
Authors: Dayom, D. W.
Wannang, N. N.
Bukar, B. B.
Afedia, E.
Keywords: oral feeding
Anoge issusleiocarpus leaf
subchronic toxicity
Issue Date: 2013
Publisher: Journal of Pharmacy and Biological Sciences (IOSR - JPBS)
Series/Report no.: Vol. 8;No. 1; Pp 26-31
Abstract: Background/Purpose:- Natural products are the cornerstone of healthcare delivery in many poorresource countries like Nigeria. However, they pose great potentials for systemic toxicity which should be identified and avoided or at least minimized. Method:- The effect of Anogeissusleiocarpus leaves was tested on the haematological parameters and some isolated organ morphology of rats following subchronic oral feeding of the rats with the aqueous extract for between 7-28 days. Result:- The plant decreased (p<0.05) platelet counts at all doses in the first 7 days of treatment. After 14-day treatment, changes in WBCs, RBCs, PCV and Hb were not significant (P>0.1). However, following 28 days of treatment, RBCs, PCV and Hb increased (p<0.05) while changes in other parameters were not significant. There was no significant effect on kidney, liver and heart except a decrease (p<0.05) in dry weights of the isolated organs at 300mg/kg following 28-day treatment. There was no visible histopathologicchangs in the isolated organs sectioned. Conclusion: - Anogeissusleiocarpus leave extract caused fluctuating dose-independent changes in blood parameters and isolated organ weights. It is substantially non-toxic as the observed changes were not significant to preclude its use.
URI: http://hdl.handle.net/123456789/1639
ISSN: 2278-3008
Appears in Collections:Pharmacology

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