University of Jos Institutional Repository >
Medical Sciences >
Community Medicine >

Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/1861

Title: Prevalence of Hepatitis B E Antigen among Human Immunodeficiency Virus and Hepatitis B Virus Co-Infected Patients in Jos, Nigeria
Authors: Iroezindu, Michael O.
Daniyam, Comfort A.
Agbaji, Oche O.
Isa, Ejiji S.
Okeke, Edith N.
Imade, Godwin E.
Keywords: CD4 cell count
Issue Date: 2013
Publisher: Journal of Infection in Developing Countries (JIDC)
Series/Report no.: Vol. 7;No.13; Pp 951-959
Abstract: Introduction: Human immunodeficiency virus (HIV) negatively impacts the natural history of hepatitis B virus (HBV) infection, including replication. We determined the prevalence of HBeAg in HIV/HBV co-infected patients compared to HBV mono-infected controls and further investigated the relationship between HBeAg seropositivity and the degree of HIV-induced immunosuppression in co-infected patients. Methodology: The study design was cross-sectional. One hundred HBsAg-positive HIV-infected adults and 100 age and sex matched HBsAg-positive HIV negative controls were consecutively recruited between May and November 2010. Relevant demographic and HBVrelated information was obtained. HBeAg was assayed by semi-quantitative third generation ELISA. The HIV/HBV co-infected patients also had CD4+ cell and HIV viral load quantification measured using flow cytometry and polymerase chain reaction techniques respectively. Results: In each group, the mean age was 34 ± 8 years and the majority (61%) was female. The prevalence of HBeAg was significantly higher among co-infected patients (n = 28; 28%) than in the controls (n = 15; 15%; p = 0.03). HBeAg seropositivity was independently associated with age < 40 years (AOR = 2.83, 95% = CI 1.29-6.17) and HIV seropositivity (AOR = 2.44, 95% C.I = 1.17-5.07). The prevalence of HBeAg was significantly higher in co-infected patients with CD4 cell count < 200 cell/µL (41.3%) compared to those with 200-499 cell/µL (18.6%) and ≥500 cell/µL (9.1%), p = 0.006. Conclusion: HIV/HBV co-infected patients have a significantly higher prevalence of HBeAg than HBV mono-infected individuals. HBVinfected patients should be routinely assessed for HBeAg, especially if they are co-infected with HIV.
URI: http://hdl.handle.net/123456789/1861
Appears in Collections:Community Medicine

Files in This Item:

File Description SizeFormat
2747-25989-1-PB.pdf616.84 kBAdobe PDFView/Open
View Statistics

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.


Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback