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|Title: ||Prevalence of Hepatitis B E Antigen among Human Immunodeficiency Virus and Hepatitis B Virus Co-Infected Patients in Jos, Nigeria|
|Authors: ||Iroezindu, Michael O.|
Daniyam, Comfort A.
Agbaji, Oche O.
Isa, Ejiji S.
Okeke, Edith N.
Imade, Godwin E.
|Keywords: ||CD4 cell count|
|Issue Date: ||2013|
|Publisher: ||Journal of Infection in Developing Countries (JIDC)|
|Series/Report no.: ||Vol. 7;No.13; Pp 951-959|
|Abstract: ||Introduction: Human immunodeficiency virus (HIV) negatively impacts the natural history of hepatitis B virus (HBV) infection, including replication. We determined the prevalence of HBeAg in HIV/HBV co-infected patients compared to HBV mono-infected controls and further investigated the relationship between HBeAg seropositivity and the degree of HIV-induced immunosuppression in co-infected patients. Methodology: The study design was cross-sectional. One hundred HBsAg-positive HIV-infected adults and 100 age and sex matched HBsAg-positive HIV negative controls were consecutively recruited between May and November 2010. Relevant demographic and HBVrelated information was obtained. HBeAg was assayed by semi-quantitative third generation ELISA. The HIV/HBV co-infected patients also had CD4+ cell and HIV viral load quantification measured using flow cytometry and polymerase chain reaction techniques respectively. Results: In each group, the mean age was 34 ± 8 years and the majority (61%) was female. The prevalence of HBeAg was significantly higher among co-infected patients (n = 28; 28%) than in the controls (n = 15; 15%; p = 0.03). HBeAg seropositivity was independently associated with age < 40 years (AOR = 2.83, 95% = CI 1.29-6.17) and HIV seropositivity (AOR = 2.44, 95% C.I = 1.17-5.07). The prevalence of HBeAg was significantly higher in co-infected patients with CD4 cell count < 200 cell/µL (41.3%) compared to those with 200-499 cell/µL (18.6%) and ≥500 cell/µL (9.1%), p = 0.006. Conclusion: HIV/HBV co-infected patients have a significantly higher prevalence of HBeAg than HBV mono-infected individuals. HBVinfected patients should be routinely assessed for HBeAg, especially if they are co-infected with HIV.|
|Appears in Collections:||Community Medicine|
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