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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/1869

Title: HIV and risk of type 2 diabetes in a large adult cohort in Jos, Nigeria
Authors: Isa, Samson E.
Oche, Agbaji O.
Kang’ombe, Arthur R.
Okopi, Joseph A.
Idoko, John A.
Cuevas, Luis E.
Gill, Geoffrey V.
Issue Date: 2016
Publisher: Clinical Infectious Diseases Advance Access published
Series/Report no.: ;Pp.1 – 18
Abstract: Background: HIV infection and the use of anti-retroviral therapy (ART) may increase the risk of type 2 diabetes mellitus (T2DM). However, data from regions with a high burden of HIV/AIDS is limited. We determined the prevalence of T2DM at the time of presentation to a large HIV Clinic in Nigeria, as well as the incidence of diabetes 12 months following ART initiation. Methods: Data from patients enrolled for ART from 2011 to 2013 was analyzed, including 2632 patients on enrollment and 2452 re-evaluated after 12 months of ART commencement. The presence of diabetes, demographic, clinical and biochemical data were retrieved from standardized databases. CD4+, HIV viral load, and hepatitis C virus (HCV) status were noted. Bivariate and logistic regressions were used to identify risk factors for T2DM. Results: Baseline T2DM prevalence was 2.3% (95%CI: 1.8% – 2.9%), and age, but not body mass index (BMI) was a risk factor for diabetes. After 12 months of ART, a further 5.3% had developed T2DM. Newly developed diabetes was not associated with age, but was associated with BMI. There were no significant associations between prevalent or incident diabetes and CD4+, viral load or type of ART. Conclusions: Diabetes is not uncommon in HIV infected individuals at the time of presentation to HIV services. Patients initiating ART then have a high risk of developing diabetes in the first year of ART. Incident diabetes was associated with a BMI ≥ 25.0, and excessive weight gain should be avoided.
URI: http://hdl.handle.net/123456789/1869
Appears in Collections:Community Medicine

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