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|Title: ||Combined Anti-diabetic Effects of Extracts of Artemisia annua var. chiknensis (CBGE/CHNA/09/LTNGS/G) and Each of Three other Plants (Momordica charantia Linn. Vernonia amygdalina Del. and Aegle marmelos Correa) Traditionally Used in Nigeria for the Treatment of Diabetes|
|Authors: ||Ogbonna, C. I. C.|
Ogbonna, A. I.
Onyimba, I. A.
Itelima, J. U.
Umar, A. F.
Istifanus, M. F.
|Keywords: ||Diabetes mellitus|
|Issue Date: ||2017|
|Publisher: ||Journal of Scientific Research & Reports|
|Series/Report no.: ||Vol. 16;No. 2; Pp 1-12|
|Abstract: ||The combined anti-diabetic effects of Extracts of Artemisia annua var. chiknensis with Laboratory
code number (CBGE/CHINA/09/LTNGS/G), Momordica charantia Linn, Vernonia amygdalina Del.
and Aegle marmelos Correa traditionally employed in Nigeria for the treatment of diabetes were
studied. Fifty male albino rats which had been subjected to overnight fasting were rendered
diabetic through single intraperitoneal alloxan injections (120 mg/kg body weight). They were then
divided into 5 batches of ten rats each. The first batch was treated with A. annua leaf extract only.
The second batch was treated with a combination of A. annua and M. charantia extracts. The third
batch was treated with a combination of A. annua and V. amygdalina extracts while the fourth
batch was treated with a combination of A. annua and Aegle marmelos extracts. The extracts were
used in the ratio of 1:1 and treatment was done twice daily for a period of 30 days. The fifth batch
of diabetic rats was not treated and thus served as control. The sixth batch of non-diabetic rats (10)
was set up for comparison. Both the A. annua extract and its various combinations with the other
experimental plant extracts resulted in insulin level enhancements and fasting blood glucose level
reductions of the diabetic rats. There were significant differences (P≤0.05) in the insulin level of
diabetic rats treated with A. annua leaf extract alone and those treated with different combinations
of the plant extracts. The mean effects of the extracts on insulin and fasting blood glucose levels
were most significant in A. annua + M. charantia (38.65 μlU/ml and 87.55 mg/dl) and A. annua + A.
marmelos (38.55 μlU/ml and 87.92 mg/dl) treatments at P≤0.05. The non-treated diabetic rats had
an average body weight of 94.90 g as compared to the original average body weight of 100 g at the
commencement of the study. The treated diabetic rats had average body weight increments from
108.83g to 109.29 g. The non-diabetic rats had an average body weight of 114.10 g as compared
to their initial average body weight of 100 g. The experimental plants were found to contain various
biochemical constituents which were probably responsible for the blood serum insulin level
enhancements and fasting blood glucose level reductions.
The results obtained have shown that the A. annua leaf extract and its combinations with the other
plant extracts could be employed in the management of hyperglycemia.|
|Appears in Collections:||Plant Science and Biotechnology|
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