University of Jos Institutional Repository >
Veterinary Medicine >
Veterinary Physiology, Biochemistry and Pharmacology >
Please use this identifier to cite or link to this item:
|Title: ||The Organophosphate, Chlorpyrifos, Oxidative Stress and the Role of Some Antioxidants: A Review|
|Authors: ||Uchendu, Chidiebere|
Ambali, Suleiman F.
Ayo, Joseph O.
|Issue Date: ||2012|
|Publisher: ||African Journal of Agricultural Research|
|Series/Report no.: ||Vol. 7;No. 18; Pp 2720-2728|
|Abstract: ||The present paper reviews the current state of our knowledge of the role of oxidative stress in the mechanism underlying chlorpyrifos poisoning, and the role of some antioxidants in ameliorating
adverse effect of pesticides. In order to understand better the nature of oxidative stress, the principle of
free radical generation, the body’s normal defense system including antioxidants are discussed. The
adverse health effects of the organophosphate, chlorpyrifos and their ability to induce oxidative stress
through the generation of free radicals and alteration in body antioxidant status were also discussed.
Some antioxidant molecules that have been proven to mitigate against chlorpyrifos induced toxicity
were also enumerated. It is concluded that the generation of reactive oxygen species induces oxidative
damages and disturbances of the antioxidant body defence systems, which are implicated in the
mechanisms of toxicity in most pesticides, including chlorpyrifos were inhibited by some of the
antioxidants. It is recommended that further research be geared towards identifying more agents that
may ameliorate chlorpyrifos and other organophosphates of adverse effects.|
|Appears in Collections:||Veterinary Physiology, Biochemistry and Pharmacology|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.