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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/2140

Title: The Mechanism of Action and Effect on the Cervix of the Seed of Ricinus communis Var. Minor (RICOM-1013-J) in Women Volunteers in Nigeria
Authors: Iornmube, Usar Joseph
Ekwere, Ekwere Okon
McNeil, Rosaleen Thecla
Francis, Okwuasaba Kanayo
Keywords: oestrogenic
intraepithelial neoplasia
Issue Date: 2016
Publisher: Journal of Natural Sciences Research
Series/Report no.: Vol. 6;No. 24; Pp 64-70
Abstract: The seeds of Ricinus communis var minor (RICOM-1013-J) have been reported to prevent conception for a year, when taken as single oral dose of 2.5-2.7 gm. This study was undertaken to investigate the possible hormonal changes mediating its activity and also evaluate any potential relationship with cervical intraepithelial neoplasia in women. Sixty women volunteers attending a traditional herbal clinic in Jos, were recruited for this study and divided into treatment and control groups of 30 each. The study showed that RICOM-1013-J protected women participants against conception for a duration of 12 months, while maintaining regular menstrual cycles. Nausea, vomiting, weight gain, raised blood pressure and menstrual abnormalities commonly experienced with conventional oral contraceptive were absent. Further findings revealed a statistically significant elevation in plasma levels of prolactin in women administered RICOM-1013-J compared to controls (p<0.05). However, there was no significant difference in FSH and LH plasma levels between both groups. In addition, the prevalence of cervical intraepithelial neoplasia between women who received RICOM-1013-J and control group was not statistically significant (p>0.05). It is possible therefore, that RICOM-1013-J may act in part through an oestrogen induced hyper- prolactinaemic hypogonadal mechanism. This study has provided the first insight of hormonal changes in human volunteers administered RICOM-1013-J as contraceptive agent.
URI: http://hdl.handle.net/123456789/2140
ISSN: 2225-0921
Appears in Collections:Pharmacology

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