University of Jos Institutional Repository >
Pharmaceutical Sciences >
Pharmacology >

Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/2179

Title: Antidiabetic Effect of Methalonic Leaf Extract of Pterocarpus Erinaceus in Streptozotocin Induced Diabetic Rats
Authors: Ajayi, Victoria Folashade
Uguru, M.O.
Suleiman, Daniel
Ajayi, Abraham Dare
Keywords: Diabetes mellitus
Blood glucose
Pterocarpus erinaceus Diabetic rats
Issue Date: 2017
Publisher: Scientific Research Journal (SCIRJ)
Series/Report no.: Vol. 5;Iss. 3; Pp 1-6
Abstract: The plant Pterocarpus erinaceus has been widely utilized Phytotherapeutically for it anti-mycotic, anti-helminthics, anti-malaria, anti-gonadotropic activities. The anti-diabetic effect was investigated using the methanolic leaf extract of the plant on male albino rats by monitoring the Blood Glucose Concentration before and after the treatment. Phytochemical screening of the plant reveals the presence of Saponins, Tannins, Flavonoids, Alkaloids, Steroids, Carbohydrates and Cardiac glycosides. Acute toxicity study of the methanolic leaf extract of the plant was greater than 5000mg/kg when administered via the oral route. The fasting blood glucose concentration of the animals was determined at day 0 then at day 1, 4 and 7 post administration. At day 4 and day 7, there was significant (p < 0.05) reduction in the blood glucose concentration of the group that receive 250mg/kg, 500 mg/kg, 1000mg/kg of the extract. There was no significant change in the weight of the animal across the group. The result indicates that the methanolic leaf extract of Pterocarpus erinaceus Poir has anti-diabetic activity as it reduces the blood glucose concentration from 330mg/dl to 117mg/dl. This study shows possible beneficial effects of Pterocarpus erinaceus in the management of diabetes.
URI: http://hdl.handle.net/123456789/2179
ISSN: 2201-2796
Appears in Collections:Pharmacology

Files in This Item:

File Description SizeFormat
scirj-P0417395.pdf175.03 kBAdobe PDFView/Open
View Statistics

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.


Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback