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|Title: ||Prevalence of Sickle Cell Disease among Children Attending Plateau Specialist Hospital, Jos, Nigeria|
|Authors: ||Stephen, Nanbur|
Gusen, Nanle Joseph
Kumzhi, Patience Ringkat
Auta, Dauda Abimiku
Bulndi, Lydia B.
Kumari, Vasantha P.
|Issue Date: ||5-Jun-2018|
|Publisher: ||Acta Medica International |
|Citation: ||Stephen N, Nden N, Gusen NJ, Kumzhi PR, Gaknung B, Auta DA, et al. Prevalence of sickle cell disease among children attending plateau specialist hospital, Jos, Nigeria. Acta Med Int 2018;5:20-3|
|Series/Report no.: ||Vol. 5;No. 1: Pp 20-23|
|Abstract: ||Background: An estimate of 250,000 children are born annually with sickle cell disease (SCD) worldwide and 75%–85% of the affected
children are born in Africa; where mortality rates for those under age 5 years range from 50% to 80%. Objective: The present study was
conducted to estimate the prevalence of SCD among children in Plateau State Specialist Hospital (PSSH), Jos, Nigeria. Methodology: Ethical
approval was obtained from the Health Research Ethics Committee of the Hospital. Secondary data on age, gender, and region from the case
notes of infants, children and/or adolescents; who received medical care in PSSH from 2012 to 2014 were used. Data were analyzed using
frequency tables and Chi‑square statistics. Results: The findings revealed that the prevalence of SCD in PSSH, Jos from 2012 to 2014 was
26.9/1000 population of pediatric patients. There was a gradual increase in the prevalence rate from 25.8/1000 in 2012 to 26.8/1000 in 2013
and 28.1/1000 in 2014. However, the case fatality rate of SCD gradually decreased from 15.4% in 2012 to 11.1% in 2013 and 10.3% in 2014.
Chi‑square test shows that the prevalence of the disease in relation to sex, age, and residence was not statistically significant (P > 0.05). Even
though the case fatality rate of the disease decreased, its prevalence increased during the study. Conclusion: Therefore, preventive measure
for SCD such as premarital genetic screening and counseling should be emphasized, especially in the southern and central geopolitical zones
of Plateau state, where the prevalence was found to be higher.|
|Appears in Collections:||Zoology|
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