Acetyl-L-carnitine attenuates haemotoxicity induced by subacute chlorpyrifos exposure in Wistar rats

Abstract

The present study was aimed at evaluating the effect of subacute CPF exposure on haematological changes and the ameliorating effect of acetyl-L-carnitine (ALC) in Wistar rats. Twenty-eight adult male Wistar rats divided into 4 groups of 7 animals each were used for the study. Groups I and II were given soya oil (2 mlkg⁻¹) and ALC (300 mgkg⁻¹), respectively. Group III received CPF only (8.5 mgkg⁻¹~1/10th of the LD50) while group IV was pretreated with ALC (300 mgkg-1), and then dosed with CPF (8.5 mgkg⁻¹), 30 min later. The regimens were administered by gavage once daily for 28 days. The study showed that haematological parameters such as total red blood cell, packed cell volume, haemoglobin concentration, mean cell volume, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration, platelets, absolute total and differential white blood cell count, neutrophil-lymphocyte ratio and erythrocyte osmotic fragility altered by CPF were ameliorated by pretreatment with ALC.