University of Jos Institutional Repository >
Medical Sciences >
Chemical Pathology >
Please use this identifier to cite or link to this item:
|Title: ||Reference Interval of Thyroxine and Thyrotropin of Healthy Term Nigerian Newborns in Jos University of Teaching Hospital|
|Authors: ||Ishaku, Affi Ayuba|
Shabbal, Dalili Mohammed
|Issue Date: ||2017|
|Publisher: ||Jos Journal of Medicine|
|Series/Report no.: ||Vol.11;No.1; Pp 26-30|
To establish a local Reference Interval of Serum Thyroxine (T4) and Serum Thyroid stimulating
Hormone(TSH) of healthy Nigerian Newborns in Jos University Teaching Hospital Jos.
Materials and Methods:
One hundred and sixty healthy term Nigerian Newborns who fulfilled the criteria for inclusion were selected
by simple random sampling.
Cord blood sample taken from the Newborns were analyzed for levels of T and TSH (Thyroid stimulating 4
hormone) using the Enzyme Link Immunosorbent assay (ELISA) method.
Reference intervals were determined by Rank Procedure of non- parametic method.
TSH Mu/LReference Interval
Lower reference limit 0.22 (0.21 – 0.23) mU/L
Upper reference limit 29.2 (21.8 – 29.2) mU/I
Reference Interval = 0.21 – 29.2 mU/L
TSH Mean = 3.31mU/L± 2.56
T4 nmol/LReference Interval
Lower reference limit 63.0 (55.0 – 66.0)
Upper reference limit 201.2 (201.1 – 202.9)
Reference interval = 63.0 – 202.9
T Mean = 143.5 ± 136 nmol/L 4
This study revealed the serum values of T and TSH in these healthy Nigerian Newborns. These values can be 4
used to diagnose congenital hypothyroidism (CH) and ultimately used for screening for congenital
hypothyroidism in this region of iodine deficiency disorder (IDD). This may form a basis for establishing a
neonatal screening program in collaboration with pediatricians in this region as CH is one of the commonly
screened inborn errors of metabolism.|
|Appears in Collections:||Chemical Pathology|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.