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|Title: ||Cancer genetics – A review|
|Authors: ||Jaryum, Kiri H.|
Deme, Amstrong S.
Daniang, Ishaya E.
Binjin, Daniel N.
|Issue Date: ||2008|
|Publisher: ||International Journal of Biological and Chemical Sciences|
|Series/Report no.: ||Vol. 2;Iss. 4; Pp 587-591|
|Abstract: ||Changes in DNA are the fundamental cause of cancers. These changes are brought about by
chemicals, viruses, radiation, and mistakes made each day in the course of duplicating the billions
of units in the DNA when a cell divides. Genes, the central molecules of life, are very vulnerable to
damage. However, each cell has a remarkable ability to recognize damage and repair it. The
imbalance between damage and the cell’s ability to repair the damage results in the changes
required in DNA to produce cancer. Because of hereditary predisposition or environmental factors
or both, the DNA repair mechanisms – tumour suppressors – become defective and hence leading to
accumulation of errors (mutations) throughout the genome. In times, genes important in controlling
cell proliferation – cellular oncogenes – become altered; resulting in altered gene products necessary
for cell cycle control. Loss of control over the cell cycle is the onset of cancer and its eventual
progression. It was therefore concluded that, cancer is a disease of the genes. Further investigation
into the matter was recommended.|
|Appears in Collections:||Biochemistry|
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