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Title: | Short Report: Comparison of Chlorproguanil-Dapsone with a Combination of Sulfadoxine-Pyrimethamine and Chloroquine in Children with Malaria in Northcentral Nigeria |
Authors: | Oluwagbenga, Ogunfowokan Musa, Dankyau Aboi, J.K Madaki Tom, D. Thacher |
Issue Date: | 2009 |
Series/Report no.: | Vol.80;No.2 |
Abstract: | Abstract. Effective and affordable treatment of malaria is critical in the face of resistance of Plasmodium falciparum
to chloroquine (CQ) and sulfadoxine-pyrimethamine (SP). We conducted a randomized controlled trial comparing the
efficacy of chlorproguanil-dapsone (CD) with a combination SP plus CQ in children in Nigeria less than five years of age
with malaria. Of 264 children enrolled, 122 (89.7%) and 118 (92.2%) completed the study in the SP + CQ and CD groups,
respectively. By day 3, 96 (78.7%) and 94 (79.7%) had cleared their parasitemia ( P = 0.79), and 107 (87.7%) and 109
(92.4%) were symptom free ( P = 0.32) in the SP + CQ and CD groups, respectively. Adequate clinical and parasitologic
response at day 14 occurred in 111 (94.1%; 95% confidence interval [CI] = 91.6–95.7%) in the CD group and 113 (92.6%;
95% CI = 89.9–94.3%) in the SP + CQ group ( P = 0.85). SP + CQ and CD had similar antimalarial efficacy and still
provide affordable treatment of uncomplicated malaria in northcentral Nigeria. |
URI: | http://hdl.handle.net/123456789/292 |
Appears in Collections: | Family Medicine
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