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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/3484

Title: A Comparison of Sulfadoxine-Pyrimethamine with Chloroquine And Pyrimethamine for Prevention of Malaria in Pregnant Nigerian Women
Authors: Tukur, Ibrahim U.
Thacher, Tom D.
Sagay, Atiene S.
Madaki, Jeremiah K. A.
Issue Date: 2007
Publisher: American Journal of Tropical Medicine and Hygiene
Series/Report no.: Vol. 76;Iss Pp 1019–1023
Abstract: Few studies have documented the effectiveness in west Africa of intermittent preventive treatment of malaria with sulfadoxine-pyrimethamine (SP) in pregnancy. Pregnant Nigerian women were assigned to receive either SP given twice or presumptive chloroquine (CQ) treatment followed by weekly pyrimethamine (CQ + P); 250 were enrolled in each group. Of those completing follow-up, 4 (1.8%) in the SP group and 22 (9.8%) in the CQ + P groups had a febrile illness (P 0.005). None in the SP group but 11 (4.9%) in the CQ + P group had peripheral parasitemia prior to or during delivery (P 0.002). Two (1.2%) in the SP group and 9 (5.0%) in the CQ + P group were anemic at delivery (P 0.04). There were six low birth weight infants in the SP group and eight in the CQ + P group (P 0.21). Intermittent preventive treatment with SP is superior to CQ + P for prevention of malaria and anemia in pregnant women in Nigeria.
URI: http://hdl.handle.net/123456789/3484
Appears in Collections:Family Medicine

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