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|Title: ||Impact of Hepatitis C Virus on HIV Response to Antiretroviral Therapy in Nigeria|
|Authors: ||Agbaji, Oche|
Thio, Chloe L
|Issue Date: ||1-Feb-2013|
|Publisher: ||Journal of Acquired Immune Deficiency Syndromes|
|Series/Report no.: ||Vol.63;No.2;Pp 204-207|
|Abstract: ||The effect of hepatitis C virus (HCV) on antiretroviral
therapy (ART) response in patients in sub-Saharan Africa is unknown.
We studied 1431 HIV-infected ART initiators in Jos, Nigeria, of whom
6% were HCV coinfected. A similar proportion of HIV/HCV-coinfected
and HIV-monoinfected patients achieved HIV RNA ,400 copies per
milliliter after 24 and 48 weeks of ART (P . 0.05). Hepatotoxicity was
uncommon (0.8% and 0.33% at 24 and 48 weeks, respectively) but was
more common in the HIV/HCV-coinfected group at 24 (adjusted odds
ratio = 19.3; 95% confidence interval: 4.41 to 84.4) and 48 weeks
(adjusted odds ratio = 56.7; 95% confidence interval: 5.03 to 636.92).
HCV did not significantly impact ART response in this Nigerian cohort.|
|Appears in Collections:||Medicine|
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