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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/351

Title: Impact of Hepatitis C Virus on HIV Response to Antiretroviral Therapy in Nigeria
Authors: Agbaji, Oche
Thio, Chloe L
Meloni, Seema
Graham, Camilla
Muazu, Mohammed
Nimzing, Ladep
Idoko, John
Sankalé, Jean-Louis
Ekong, Ernest
Murphy, Robert
Kanki, Phyllis
Hawkins, Claudia
Keywords: Africa
Issue Date: 1-Feb-2013
Publisher: Journal of Acquired Immune Deficiency Syndromes
Series/Report no.: Vol.63;No.2;Pp 204-207
Abstract: The effect of hepatitis C virus (HCV) on antiretroviral therapy (ART) response in patients in sub-Saharan Africa is unknown. We studied 1431 HIV-infected ART initiators in Jos, Nigeria, of whom 6% were HCV coinfected. A similar proportion of HIV/HCV-coinfected and HIV-monoinfected patients achieved HIV RNA ,400 copies per milliliter after 24 and 48 weeks of ART (P . 0.05). Hepatotoxicity was uncommon (0.8% and 0.33% at 24 and 48 weeks, respectively) but was more common in the HIV/HCV-coinfected group at 24 (adjusted odds ratio = 19.3; 95% confidence interval: 4.41 to 84.4) and 48 weeks (adjusted odds ratio = 56.7; 95% confidence interval: 5.03 to 636.92). HCV did not significantly impact ART response in this Nigerian cohort.
URI: http://hdl.handle.net/123456789/351
Appears in Collections:Medicine

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