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Title: | In Vivo Antioxidant and Toxicity Properties of Methanol Root Extract of Ximenia Americana, L. (Olacaceae) in Drosophila Melanogaster |
Authors: | Bagu, G. D Omale, S Iorjiim, W. M Etu, M. A Ochala, S. O Gyang, S. S. Aguiyi, J. C |
Keywords: | Free radical Oxidative stress |
Issue Date: | 2020 |
Publisher: | International Journal of Engineering Applied Sciences and Technology |
Series/Report no.: | Vol. 4;Iss. 12; Pp59-66 |
Abstract: | Antioxidants are chemical molecules that serve as defensive agents in biological systems against the harmful effects of free radicals and are very important in
maintaining the optimal function of the body. The
antioxidant and toxicity properties of Ximenia americana
methanol root extract were investigated using the
Drosophila melanogaster model. Findings from the
research showed that the extract caused an increase in the
activities of all the Oxidative stress biological markers;
Catalase, Total thiol, Glutathione-S-transferase, and
Superoxide dismutase investigated in a concentration dependent manner, but the increased observed was not
significant (P> 0.05) compared to the control. Also, the
concentrations (5 mg, 20 mg, and 60 mg) used in the
studies improved non-significantly (P>0.05) the survival of
the treated groups in D. melanogaster when compared to
the control. The present study revealed that X. americana
root is relatively safe and has potent antioxidant activity
due to an increased in the activity of the antioxidant
enzymes (catalase, Total thiol, Glutathione-S-transferase)
by the extract as such can be employed in the management
of diseases that are implicated in oxidative stress. |
URI: | http://hdl.handle.net/123456789/3552 |
ISSN: | 2455-2143 |
Appears in Collections: | Pharmacology
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