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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/397

Title: Anticonvulsant Activity of Some N, N'-(2,3,5,6- Tetramethyl-l,4-Phenylene) Bis (4-Substituted Benzamides)
Authors: Afolabi, E.O.
Ebuga, Solomon
Keywords: Epilepsy,
Seizures.
Issue Date: 2006
Series/Report no.: ;Pp 7-11
Abstract: The anticonvulsant activity of four analogues of N,N'-(2,3,5,6-tetramethyl-I,4-phenylene) bis (4- substitutedbenzamides) were determined at three dose levels in accordance with the Antiepleptic Drug Development program (ADD) of National Institute of Health (NIH), USA. These compounds are analogues of 4-amino-N-(2,6- dimethylphenyl)benzamide (Ameltolide┬«, or LY20 1116) which is the most potent benzamide anticonvulsant studied to date. The result of our anticonvulsant screening confirmed the superiority of 4-aminobenzamides over other parasubstituted analogues.
Description: PROCEEDINGS OF THE NEUROSCIENCE SOCIETY OF NIGERIA (NSN) CONFERENCE, JOS.
URI: http://hdl.handle.net/123456789/397
Appears in Collections:Pharmaceutical Chemistry

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