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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/426

Title: Assessment of the Vitamin B12 Status of Pregnant Women in Nigeria Using Plasma Holotranscobalamin
Authors: Vanderjagt, Dorothy J.
Ujah, Innocent A.O.
Ikeh, Eugene I.
Bryant, Jessica
Pam, Victor
Hilgart, Amilia
Crossey, Michael J.
Glew, Robert H.
Issue Date: 2011
Publisher: International Scholarly Research Network ISRN Obstetrics and Gynecology
Series/Report no.: Pp 1-8;
Abstract: Maternal vitamin B12 deficiency during pregnancy is an independent risk factor for neural tube defects and other neurological problems in infants. We determined the vitamin B12 status of 143 pregnant women in Nigeria representing all trimesters who presented to an antenatal clinic in Jos, Nigeria, using holotranscobalamin II levels (holoTCII), which is a measure of the vitamin B12 that is available for uptake into tissues. The holoTCII concentration ranged from 13 to 128 pmol/L. Using a cutoff of 40 pmol/L, 36% of the women were classified as vitamin B12-deficient. HoloTCII concentrations correlated negatively with plasma homocysteine levels (r = −0.24, P = 0.003) and positively with red blood cell folate concentrations (r = 0.28,P < 0.001). These data underscore the importance of supplementing pregnant women in Nigeria with vitamin B12 in order to ensure adequate vitamin B12 status and decrease the risk for neural tube defects.
URI: http://hdl.handle.net/123456789/426
Appears in Collections:Obstetrics and Gynaecology
Medical Microbiology

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