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Title: Prevalence and Distribution of Candida Species in HIV Infected Persons on Antiretroviral Therapy in Jos
Authors: Lar, P.M
Pam, K.V
Tiri, Yop
Olukose, Shola
Yusuf, Agabi
Dashen, M.M
Mawak, J.D
Keywords: Characterization,
Issue Date: Apr-2012
Publisher: Journal of Medicine and Medical Science
Series/Report no.: Vol.3;No.4;Pp 254-259
Abstract: Oropharyngeal candidiasis (OPC) is commonly associated with HIV. The causative agent is a yeast strain that is originally present as a commensal of the oral cavity. Most species of the genus Candida that cause OPC in HIV patients if not identified and properly treated with the drug of choice could result in resistance to the drugs and make treatment very difficult. This study was carried out to establish the species spectrum of the common yeasts associated with OPC in HIV patients on antiretroviral treatment in Jos, A total of 248 samples was collected; one hundred and ninety eight (198) Throat swabs from HIV seropositive males and females at the 2 hospitats.sn control samples from HIV seronegative persons were collected. The samples were cultured on Saburauds dextrose agar and Candida Species isolated were characterized using germ tube test and sugar fermentation tests. Out of 248 subjects (HIV positive and HIV negative individuals) were examined for oropharyngeal candidiasis,24(9.68%) yielded Candida growth. The age group 36-4S years accounted for the highest number 12 (SO%) of isolates. Candida albicans accounted for 19 (79.2%) of the isolates,Candida pseudotropicalis 2 (8.3%), while Candida tropicalis, Candida parapsilosis and Candida guilliermondi had 1 (4.2%) isolates each. More women18 (7.26%) had oropharyngeal candidiasis than men 6(2.41%). 10% of the population studied were found to be colonized with Candida. HIV patients whether or not on drugs were predisposed to oropharyngeal candidiasis. C. albicans is the commonest species associated followed by, C. pseudotropicalis, C. tropicalis, C. parapsilosis and C.guilliermondi.Among patients on ART, Candida albicans was most prevalent 14(S8.33%). Candida guilliermondi was the only species of Candida found in HIV positive patients not on ARV.Candida albicans still remains the leading cause of oropharyngeal candidiasis in HIV infected persons within the study population.Constant identification of isolates of yeasts infecting HIV infected persons and the immune compromised will further enhance the appropriate treatment and minimise the speedy emergence of antifungal resistance.
URI: http://hdl.handle.net/123456789/455
Appears in Collections:Microbiology

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