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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/503

Title: Clinical Characteristics and Predictors of Mortality in Hospitalized HIV-Infected Nigerians
Authors: Agaba, Patricia .A
Digin, Eunice
Makai, Rahila
Apena, Labake
Agbaji, Oche .O
Idoko, John .A
Murphy, Rob
Kanki, Phyllis
Issue Date: 2011
Publisher: The Journal of Infection in Developing Countries
Series/Report no.: Vol.5;No.5;Pp 377-382
Abstract: Introduction: Human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) is a chief cause of death in sub-Saharan Africa. In this study, the clinical characteristics and predictors of mortality among hospitalized HIV infected adult Nigerians are reported. Methodology: The records of 354 patients were reviewed for demographic and clinical characteristics. Predictors of mortality using logistic regression in a retrospective study were also reviewed. Results: A total of 109 (30.8%) males and 245 (69.2%) females participated in the study. The mean age of all participants was 35 ± 8 years. Median baseline CD4 cell counts and viral load were 91 cells/mm³ and 63,438 copies/ml respectively. There was a total of 123 (34.8%) deaths while 231 (65.2%) patients were discharged home. Tuberculosis (TB) was the most common diagnosis on admission as well as the leading cause of death. Among all subjects, only male gender (adjusted odds ratio [AOR] 4.67, 95% confidence interval [CI]: 2.63-8.29); CD4 cell count ≤ 200 cells/mm3 (AOR 5.28, 95% CI: 2.99-9.31); length of hospital stay < 3 days (AOR 4.77, 95% CI: 1.35-16.86); and age ≥ 35 years (AOR 2.43, 95% CI: 1.41-4.19) were predictive of death. Conclusion: These findings illustrate the need for early diagnosis of HIV infection, appropriate treatment and prevention of opportunistic infections, and improved access to highly active antiretroviral therapy (HAART).
URI: http://hdl.handle.net/123456789/503
Appears in Collections:Medicine

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