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|Title: ||Antihyperglycemic Activity of Leaf Essential Oil of Citrus sinensis (L.) Osbeck on Alloxan- Induced Diabetic Rats|
|Authors: ||Muhammad, N.O.|
|Issue Date: ||28-Jul-2013|
|Publisher: ||Annual Review and Research in Biology|
|Series/Report no.: ||Vol.3;No.4;Pp 825-834|
|Abstract: ||Aim: The aim of this study was to investigate the antihyperglycemic activity of leaf
essential oil of Citrus sinensis (Rutaceae) in alloxan –induced diabetic rats.
Methodology: Diabetes was induced in albino rats by intraperitoneal administration of
single dose of alloxan monohydrate (150 mg/kg body weight). The leaf essential oil of
Citrus sinensis at a dose of 110 mg/kg b.wt was administered every other day to the
diabetic rats for a period of 15 days. The effects of leaf essential oil on blood glucose,
hepatic glucose and glycogen were evaluated. 14.2 mg/kg body weight of metformin was
used as a reference drug.
Results: Intraperitoneal administration of the oil to diabetic rats led to a significant
reduction (P = .05) of fasting blood glucose and hepatic glucose levels while hepatic
glycogen significantly increased (P = .05) when compared to diabetic control animals.
Conclusion: It is concluded that leaf essential oil of Citrus sinensis possesses significant
antihyperglycemic effect on alloxan – induced diabetic rats at the dose tested.|
|Appears in Collections:||Science Laboratory Technology|
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