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http://hdl.handle.net/123456789/857
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| Title: | Anti-ulcer Properties of Alkaloids Isolated from the Fruit Pulp of Cucumis Metliferous (curcurbitaceae) |
| Authors: | Omale, S.
Wuyep, N.N.
Auta, A.
Wannang, N.N. |
| Keywords: | Ulcerogenic
Haemorrhages |
| Issue Date: | 2011 |
| Publisher: | International Journal of Pharmaceutical Science and Research |
| Series/Report no.: | Vol. 2;No.10; Pp 2586 - 2588 |
| Abstract: | Anti-ulcer properties of the alkaloids isolated from the fruit of Cucumis metuliferous was investigated in mice. Ethanol-induced gastric lesion was used to assess the anti-ulcer activity. In this study, there was a significant (p<0.05) decrease in haemorrhages and ulcerations of the gastric mucosa at 500 and 1000 mg/kg of the alkaloid compared with control. The activity of the extract is comparable to that of the standard control group administered ranitidine (1 mg/kg). The alkaloids of C. metuliferus showed a demonstrable potential as an anti-ulcer agent that could be used for the treatment of peptic ulcer disease. |
| URI: | http://hdl.handle.net/123456789/857 |
| ISSN: | 0975-8232 |
| Appears in Collections: | Pharmacology
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