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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/935

Title: Protective Effects of Alkaloids of Cucumis metuliferus Isolated from the Fruit Pulp on some Vital Organs
Authors: Anyanwu, A.A.
Jimam, N.S.
Dangiwa, D.A.
Wannang, N.N.
Falang, K.D.
Keywords: C. metuliferus
Cabon tetrachloride
Issue Date: 2014
Publisher: The Journal of Phytopharmacology
Series/Report no.: Vol. 3;No. 4; Pp. 259 - 263
Abstract: The protective effects of the alkaloids of Cucumis metuliferus fruit pulp on carbon tetrachloride-induced hepatotoxicity and gentamicin induced nephrotoxicity in adult albino rats were investigated. The result showed a significant (P<0.05) decrease in the levels of alkaline phosphatase (ALP), alanine transaminase (ALT), aspartate transaminase (AST) in CCL4 induced hepatotoxicity in rats. There was a significant (P<0.05) increase in the levels of the electrolytes (Na+, K+) which were dose dependent in gentamicin induced nephrotoxic rats compared to the controls. The dose dependent decrease in the level of urea was statistically significant (P<0.05), and there was a significant decrease in the levels of creatinine when 200 mg/kg of the alkaloid was administered to the rats alone. This result showed that alkaloids of C.metuliferus have protective effects on both the liver and kidney tissues.
URI: http://hdl.handle.net/123456789/935
ISSN: 2230-480X
Appears in Collections:Pharmacology

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