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Title: Short Communication: Transmitted HIV Drug Resistance in Antiretroviral-Naive Pregnant Women in North Central Nigeria
Authors: Imade, Godwin E.
Sagay, Atiene S.
Chaplin, Beth
Chebu, Philippe
Musa, Jonah
Okpokwu, Jonathan
Hamel, Donald J.
Pam, Ishaya C.
Agbaji, Oche
Samuels, Jay
Meloni, Seema
Sankale, Jean-Louis
Okonkwo, Prosper
Kanki, Phyllis
Issue Date: 2014
Publisher: AIDS Research and Human Retroviruses
Series/Report no.: Vol. 30;No. 2; Pp 127-133
Abstract: The World Health Organization (WHO) recommends periodic surveillance of transmitted drug resistance (TDR) in communities in which antiretroviral therapy (ART) has been scaled-up for greater than 3 years. We conducted a survey of TDR mutations among newly detected HIV-infected antiretroviral (ARV)-naive pregnant women. From May 2010 to March 2012, 38 ARV-naive pregnant women were recruited in three hospitals in Jos, Plateau state, north central Nigeria. Eligible subjects were recruited using a modified version of the binomial sequential sampling technique recommended by WHO. HIV-1 genotyping was performed and HIV-1 drug resistance mutations were characterized according to the WHO 2009 surveillance drug resistance mutation (SDRM) list. HIV subtypes were determined by phylogenetic analysis. The women’s median age was 25.5 years; the median CD4 + cell count was 317 cells/ll and the median viral load of 16 was 261 copies/ml. Of the 38 samples tested, 34 (89%) were successfully genotyped. The SDRM rate was <5% for all ART drug classes, with 1/34 (2.9%) for NRTIs/NNRTIs and none for protease inhibitors 0/31 (0%). The specific SDRMs detected were M41L for nucleoside reverse transcriptase inhibitors (NRTIs) and G190A for nonnucleoside reverse transcriptase inhibitors (NNRTIs). HIV-1 subtypes detected were CRF02_AG (38.2%), G¢ (41.2%), G (14.7%), CRF06-CPX (2.9%), and a unique AG recombinant form (2.9%). The single ARV-native pregnant woman with SDRMs was infected with HIV-1 subtype G¢. Access to ART has been available in the Jos area for over 8 years. The prevalence of TDR lower than 5% suggests proper ART administration, although continued surveillance is warranted.
URI: http://hdl.handle.net/123456789/959
ISSN: 1931-8405
Appears in Collections:Obstetrics and Gynaecology

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