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|Title: ||Immunohistochemistry and Antigenic Expression of Five Proteins in Kaposi Sarcoma|
|Authors: ||Adisa, James O.|
Egbujo, Pamela Ogechi
Azubuike, Nkiruka C.
|Keywords: ||Girardinia heterophylla|
|Issue Date: ||2013|
|Publisher: ||International Journal of Biomedical and Advance Research|
|Series/Report no.: ||Vol. 4;No. 9; Pp 574-578|
|Abstract: ||Introduction: Kaposi sarcoma poses problems in histological diagnosis because of its broad morphologic variants and
similarity to many vasoproliferative lesions. Establishing diagnosis on the basis of tumour marker alone (especially a
single result) is fraught with associated pitfalls because of the problem of non- specificity.
Method: Fifteen (15) Kaposi sarcoma biopsies from seven (7) men and eight (8) women were used to find out the gene
expression of vimentin, desmin, smooth muscle actin (SMA), S-100 and neuron specific enolase (NSE) in Kaposi
sarcoma, Haematoxylin and eosin (H&E) method was used to confirm the diagnosis of Kaposi sarcoma in archival
processed biopsies. Subsequently, Immunohistochemistry (IHC) was carried out to find out the expression of the
Results: Vimentin and SMA were found to be most reactive. Neuron specific enolase was mildly reactive while the rest
Conclusion: Only vimentin and SMA offer significant reactivity in the diagnosis of Kaposi sarcoma and are useful in
|Appears in Collections:||Medical Laboratory Sciences|
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