Renal Damage with Cotecxin and Chloroquine than with Amalar and Fansidar

Abstract

Antimalaria drugs; chloroquine, fansidar, cotecxin and amalar were administered on thirty albino rats to observe their effects on the kidney for 28 days. In the chloroquine group there was marked infiltration of the inflammatory cells in the interstitial space of the medulla. There was also the dilation of the bowman’s space and loss of brush borders of the epithelial cells. In the fansidar group, normal renal capsule with few inflammatory cells were observed and the proximal and distal convoluted tubules were moderately distorted. However, the bowman’s epithelium was not affected. In the amalar group there was marked enlargement of the glomerulus in the bowman’s space but without any associated corpuscular increase in size and the medulla was not affected. There was diffused neutrophilic infiltration in the renal cortex and mild dilation of the interstitial spaces and necrosis of the glomerulus and renal capsule infiltration with inflammatory cells in cotecxin group. It is shown in the study that continuous intake of chloroquine and cotecxin may lead to kidney disease.